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Testing Status of Nickel (II) oxide 11198-D


CASRN: 1313-99-1

Formula: Ni-O

Synonyms/Common Names

  • Nickel monoxide [Nickel and nickel compounds]

Known Uses

Chemical intermediate for stainless and alloy steels. Catalysts. Electrical devices. Thermister material. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C00862)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1.2, 2.5, 5, 10, OR 30 MG/M3; 5/GROUP.
  • 13 weeks (Inhalation)  (C00862)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.6, 1.2, 2.5, 5, OR 10 MG/M3; 10/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C00862)  Completed 
    • TR-451 (NIH Number: 96-3367)  (Peer Review Approval 11/29/1994A )
      Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, .62, 1.25, OR 2.5 M: 0, 1.25, 2.5, OR 5.0 MG/M3; 50/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (K00862)  Completed 
    • Rats: Fischer 344

Genetic Toxicology

  • Micronucleus  (A32705)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A66352)  Completed 
    •  Negative