National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11208-l

Testing Status of L-5-Hydroxytryptophan - 11208-L

 

CASRN: 4350-09-8

Formula: C11-H12-N2-O3

Synonyms/Common Names

  • 5-Hydroxy-L-trytophen (9CI)

Known Uses

Hallucinogenic drug, antidepressant, antiepileptic, precursor of serotonin (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (344778)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER82086)  Completed 
    • Citation: Teratologic Evaluation of L-5-Hydroxytryptophan in CD Rats
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 50, 100, 150, 300 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER82087)  Completed 
    • Citation: Final Report - Teratologic Evaluation of L-5-Hydroxytryptophan in CD-1 Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 50, 150, 300, 450 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.