National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11243-y

Testing Status of Tetradecanoyl phorbol acetate (TPA) - 11243-Y

 

CASRN: 16561-29-8

Formula: C36-H56-O8

Synonyms/Common Names

  • Phorbol myristate acetate
  • Tetradecanoic acid, 9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b,dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3-,4)benz(1,2-E)azulen-9-yl

Known Uses

In cancer research to study mechanisms of tumor promotion. To screen for potential inhibiting agents. Positive control for tumor promoting agents, found in croton oil (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 39 weeks (Topical Application)  (C96003D)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: TG.AC: DERMAL TPA 1.25 UG/ANIMAL/DOSE.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.