Testing Status of Tetradecanoyl phorbol acetate (TPA) 11243-Y

 

CASRN: 16561-29-8

Formula: C36-H56-O8

Synonyms/Common Names

  • Phorbol myristate acetate
  • Tetradecanoic acid, 9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b,dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3-,4)benz(1,2-E)azulen-9-yl

Known Uses

In cancer research to study mechanisms of tumor promotion. To screen for potential inhibiting agents. Positive control for tumor promoting agents, found in croton oil (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 39 weeks (Topical Application)  (C96003D)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: TG.AC: DERMAL TPA 1.25 UG/ANIMAL/DOSE.