Testing Status of Streptozotocin 11244-D

 

CASRN: 18883-66-4

Formula: C8-H15-N3-O7

Synonyms/Common Names

  • 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucose (9CI)
  • Streptozoticin

Known Uses

Chemotherapeutic agent isolated from fermentation broth of streptomyces (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C03167)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C03167)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C03167)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Organ Systems Toxicity

  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98031)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative