National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11314-j

Testing Status of 6-Methoxy-2-benzothiazolamine - 11314-J

 

CASRN: 1747-60-0

Formula: C8-H8-N2-O-S

Synonyms/Common Names

  • 2-Amino-6-methoxybenzothiazole

Known Uses

Azo dye intermediate. Used to detect occult blood in biological fluids. In polyester fibers & fabrics.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61734)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61734)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .25, 4.0 MG/GM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (773945)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (861345)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (088746)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A14091)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (353634)  Completed 
    •  Positive 
  • Salmonella  (593024)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.