National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11329-l

Testing Status of Arsine - 11329-L

 

CASRN: 7784-42-1

Formula: As-H3

Synonyms/Common Names

  • Arsenic hydride
  • Arsenic trihydride
  • Arseniuretted hydrogen
  • Arsenous hydride
  • Hydrogen arsenide

Known Uses

Agent in manufacture of electronics and light-emitting diodes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Inhalation)  (C87001)  Completed 
    • Hamsters: Syrian Golden
  • 13 weeks (Inhalation)  (C87001)  Completed 
    • Rats: Not Available; Mice: Not Available

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0226)  Completed 
    • Citation: Fowler B. Mechanisms of indium, thallium, and arsine gas toxicity: relationships to biological indicators of cell injury. In: Clarkson TW, Friberg L, Nordberg GF, and Sager PR, eds. Biological Monitoring of Toxic Metals. Rochester Series on Environmental Toxicity. New York: Plenum Press; 1988:469-478.
    • Citation: Morrissey RE, Fowler BA, Harris MW, Moorman MP, Jameson CW, Schwetz BA. Arsine: absence of developmental toxicity in rats and mice. Fundam Appl Toxicol. 1990 Aug;15(2):350-6.Pubmed Abstract
    • Male Rats: F344/N

Organ Systems Toxicity

  • Conventional Teratology (Inhalation)  (TER87038)  Completed 
    • Rats/Mice: Swiss & F344
    • Rats/Mice Maternal Negative 
    • Rats/Mice Fetal Negative 
    • Dose: 0, .025, .5, 2.5 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.