Testing Status of N,N'-methylenebisacrylamide 11410-Y

 

CASRN: 110-26-9

Formula: C7-H10-N2-O2

Synonyms/Common Names

  • 1,2-Propenamide,N,N'-methylenebis (9CI)

Known Uses

Organic intermediate. Cross-linking agent.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (878009)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (111901)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Micronucleus  (710269)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (613268)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM028)  Completed 
    • Citation: Rutledge, J.C., Cain, K.T., Kyle, J., Cornett, C.V., Cacheiro, N.L.A., Witt, K., Shelby, M.D. and Generoso, W.M. Increased incidence of developmental anomalies among descendants of carriers of methylenebisacrylamide-induced balanced reciprocal translocations. Mutation Res. 229:161-172 (1990).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Heritable Translocation Test  (HTM35)  Completed 
    • Citation: Rutledge, J.C., Cain, K.T., Kyle, J., Cornett, C.V., Cacheiro, N.L.A., Witt, K., Shelby, M.D. and Generoso, W.M. Increased incidence of developmental anomalies among descendants of carriers of methylenebisacrylamide-induced balanced reciprocal translocations. Mutation Res. 229:161-172 (1990).
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Neurotoxicology Assessment (Gavage)  (NTA94039)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N
  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB90016)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of N,N'-Methylenebisacrylamide in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, 60, 180, 360, 540, 720 PPM; 0, 10, 30, 60 PPM; 0, 60 PPM; 0, 10, 30, 60 PPM.
  • 6 to 17 GD Conventional Teratology (Gavage)  (TER90008)  Completed 
    • Citation: Final Report on the Developmental Toxicity of N,N'-Methylenebisacrylamide in Swiss (CD-1) Mice
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: REPI: 0, 30, 60, 120, 180 MG/KG REPII: 0, 3, 10, 30 MG/KG/DAY.
  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98023)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female  +, INTERVAL 1
    • +, INTERVAL 1