National Toxicology Program

National Toxicology Program

Testing Status of p-Toluidine - 11425-C


CASRN: 106-49-0

Formula: C7-H9-N

Synonyms/Common Names

  • Benzenamine,4-methyl (9CI)
  • 4-Methylaniline (4-MA)

Known Uses

Chemical intermediate for dyes. Organic synthesis. Test reagent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C11425)  On Test 
    • Rats: F344/NTac
    • Dose: MR: 0, 1, 6, 20, 60, or 120 mg/kg; 5/dose.

Genetic Toxicology

  • Salmonella  (G11425)  Completed 
    •  Negative 


  • 5 days Microarray Analysis (Gavage) Selected (T11425)  
    • Rats: F344/NTac
    • Dose: 0, 1, 6, 20, 60, or 120 mg/kg; 10 rats/group.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.