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Testing Status of o-Chloroaniline 11436-N


CASRN: 95-51-2

Formula: C6-H6-Cl-N

Synonyms/Common Names

  • 2-Chloroaniline

Known Uses

Dye intermediate; manufacture of petroleum solvents and fungicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C91001)  Completed 
    • TOX-43 (NIH Number: 98-3943)  (Tox Peer Review 09/15/1997A )
      Comparative Toxicity Studies of o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9; and 106-47-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M 0, 10, 20, 40, 80, & 160 MG/KG; 20/GRP (RATS); 10/GRP (MICE).

Genetic Toxicology

  • Mouse Lymphoma  (960448)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Micronucleus  (A07291)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A49067)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A89139)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Salmonella  (184572)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (191170)  Completed 
    •  Negative