National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11462-w

Testing Status of 5-Amino-o-cresol - 11462-W

 

CASRN: 2835-95-2

Formula: C7-H9-N-O

Synonyms/Common Names

  • 4-Amino-2-hydroxy-1-methylbenzene
  • 4-Amino-2-hydroxytoluene
  • 3-Amino-6-methylphenol
  • 3-Hydroxy-4-methylaniline

Known Uses

Used in cosmetics as coupler in oxidative hair dye

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C20214)  Completed 
    • TOX-89 (NIH Number: 16-5939)  (Tox Peer Review 12/00/2013A )
      NTP Technical Report on the Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R: 0, 2, 4, 8, 16, or 32 mg/kg; 20/sex/dose M: 0, 8, 16, 32, 64, or 128 mg/kg; 10/sex/dose.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application)  (S0852)  Completed 
    • Citation: Disposition of 5-Amino-o-cresol in Female Rats and Mice After Dermal, Oral and Intravenous Administration. November 21, 2007
    • Citation: Hedtke B, Gao Z, Chen L-J, Weber WM, Dix KJ. Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice. Xenobiotica. Feb 2008; 38(2): 171-184Pubmed Abstract
    • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N
    • Dose: 2, 20, 3.5, 35, 350 mg/kg.

Genetic Toxicology

  • Micronucleus  (A04294)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A62651)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (F62651)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (576026)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (IMM20302)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.625, 1.25, 2.5, 5, OR 10%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.