National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11538-c

Testing Status of 1,3-Dichloro-2-propanol - 11538-C

 

CASRN: 96-23-1

Formula: C3-H6-Cl2-O

Synonyms/Common Names

  • Dichlorohydrin
  • 1,3-Dichloro-2-hydroxypropane
  • 1,3-Dichloropropanol

Known Uses

Intermediate in synthesis of epichlorohydrin.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K11538)  Completed 
    • Citation: Final Study Report Identifying Prospective Metabolites, Epichlorohydrin (106-89-8) and 1,3-Dichloroacetone (534-07-6), from 1,3-Dichloro-2-Propanol (96-23-1) Metabolism in Rats and Mice
    • Male and Female Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1

Genetic Toxicology

  • Comet Assay  (G11538B)  Completed 
    • Mice
  • Micronucleus  (G11538)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (843274)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.