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Testing Status of Phenobarbital 11566-S

 

CASRN: 50-06-6

Formula: C12-H12-N2-O3

Synonyms/Common Names

  • Phenobarbituric acid

Known Uses

anticonvulsant, hypnotic, sedative

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • GD 6 to PND 21 (Gavage)  (C11566)  Completed 
    • In Utero-PND 22 Exposure to Phenobarbital
    • Rats: Wistar Han
    • Dose: 0, 5, or 45 mg/kg; 10/group.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (539978)  Completed 
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (952103)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Positive 
  • Salmonella  (338241)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Weakly Positive 

Toxicogenomics

  • Microarray Analysis (Gavage)  (T11566)  Completed 
    • In Utero - PND 22 Exposure to Phenobarbital
    • Rats: Wistar Han