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Testing Status of Pentachlorophenol, purified 11616-H

 

CASRN: 87-86-5

Formula: C6-H-Cl5-O

Known Uses

Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C54933)  Completed 
    • Mice: B6C3F1
  • 4 weeks (Dosed-Feed)  (C89002)  Completed 
    • Rats: F344/N
    • Dose: R: 0, 200, 400, 800, 1600, OR 3200 PPM; 10/SEX/GROUP.
  • 26 weeks (Dosed-Feed)  (C54933)  Completed 
    • Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C89002)  Completed 
    • TR-483 (NIH Number: 99-3973)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
    • Dose: R: 0, 200, 400, OR 600 PPM; 50/SEX/GROUP - 1000 PPM STOP STUDY (60/SEX).

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0328)  Completed 
    • Citation: Yuan JH, Goehl TJ, Murrill E, Moore R, Clark J, Hong HL, Irwin RD. Toxicokinetics of pentachlorophenol in the F344 rat. Gavage and dosed feed studies. Xenobiotica. 1994 Jun;24(6):553-60.Pubmed Abstract
    • Male and Female Rats: F344/N
    • Dose: IV 5 MG/KG BW; GAV 18.75, 75 & 150 MG/KG BW.
  • Toxicokinetic Study (Dosed-Feed)  (S0579)  Completed 
    • Male and Female Rats: F344/N
    • Dose: 200, 400 OR 600 PPM (1000 PPM STOP STUDY).