National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11619-v

Testing Status of 4,4'-Thiodianiline - 11619-V

 

CASRN: 139-65-1

Formula: C12-H12-N2-S

Synonyms/Common Names

  • 4,4'-Thiobisbenzenamine (9CI)

Known Uses

Dye intermediate

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01707)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01707)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0,1200,30000, MM: 0,2000,50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01707)  Report Complete 
    • TR-047 (NIH Number: 78-847)  (Peer Review Approval 01/18/1978A )
      Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity (CASRN 139-65-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,1500,3000, M: 0,2500,5000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (915540)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (727083)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
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