Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 4,4'-Thiodianiline 11619-V

 

CASRN: 139-65-1

Formula: C12-H12-N2-S

Synonyms/Common Names

  • 4,4'-Thiobisbenzenamine (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01707)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01707)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 1200, 30000, MM: 0, 2000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01707)  Completed 
    • TR-047 (NIH Number: 78-847)  (Peer Review Approval 01/18/1978A )
      Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity (CASRN 139-65-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 1500, 3000, M: 0, 2500, 5000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (915540)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (727083)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive