National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11620-s

Testing Status of 1,1,2-Trichloroethane - 11620-S

 

CASRN: 79-00-5

Formula: C2-H3-Cl3

Synonyms/Common Names

  • Vinyl trichloride

Known Uses

Intermediate for vinylidene chloride; solvent; in adhesives, teflon, lacquer

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04579)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04579)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04579)  Report Complete 
    • TR-074 (NIH Number: 78-1324)  (Peer Review Approval 01/18/1978A )
      Bioassay of 1,1,2-Trichloroethane for Possible Carcinogenicity (CASRN 79-00-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (834917)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (915310)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (590584)  Completed 
    •  Negative 
  • Salmonella  (624635)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (946672)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (A38940)  Completed 
    •  Equivocal 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.