National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11621-w

Testing Status of Ethionamide - 11621-W

 

CASRN: 536-33-4

Formula: C8-H10-N2-S

Synonyms/Common Names

  • 2-Ethyl-4-pyridinecarbothioamide (9CI)

Known Uses

Antitubercular drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01694)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01694)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01694)  Report Complete 
    • TR-046 (NIH Number: 78-846)  (Peer Review Approval 01/18/1978A )
      Bioassay of Ethionamide for Possible Carcinogenicity (CASRN 536-33-4)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (457178)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (292497)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (508218)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
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