National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-12011

Testing Status of Phenolic Benzotriazoles (Bumetrizole) - 12011

 

CASRN: 3896-11-5

Formula: C17-H18-Cl-N3-O

Synonyms/Common Names

  • 2-(2-Hydroxy-3-tert-butyl-5-methylphenyl)-5-chloro-2H-benzotriazole
  • PBZT

Secondary:

  • BENZOTRIAZOLES - Phenolic Benzotriazoles

Known Uses

UV Absorber; Ultraviolet screen; EPA Pesticide Inert Ingredients

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14 days (Gavage)  (C12011)  On Test 
    • Benzotriazole Class
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 30, 100, 300, or 1000 mg/kg in 0.5% aqueous methylcellulose by gavage.

Special Studies

  • Toxicokinetic Study (Gavage)  (K12011)  Report in Preparation 
    • Male Rats: Harlan Sprague-Dawley
  • Toxicokinetic Study (Intravenous)  (K12011)  Report in Preparation 
    • Male Rats: Harlan Sprague-Dawley

Genetic Toxicology

  • Micronucleus  (G12011)  On Test 
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.