National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-12103

Testing Status of Vinpocetine - 12103

 

CASRN: 42971-09-5

Formula: C22-H26-N2-O2

Synonyms/Common Names

  • Cavinton

Known Uses

Drug/therepeutic agent. Cerebrovascular agent; CNS agent; neuroprotective agent; phosphodiesterase inhibitor; vasodialator agent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Modified One-Generation

  • GD 6 - 20 Dose Range Finding (Gavage)  (MOG12103)  Assigned 
    • Perinatal
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 20, 40, 80, 160, or 320 mg/kg/day.

Special Studies

  • Toxicokinetic Study (Gavage)  (K12103)  Report in Preparation 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 5 and 20 mg/kg.

Genetic Toxicology

  • Comet Assay  (G12103D)  On Test 
    • Mice: B6C3F1
  • Micronucleus (Gavage)  (G12103B)  On Test 
    • Ranger-finder female
    • Mice: B6C3F1
  • 3 days Micronucleus (Gavage)  (G12103C)  On Test 
    • Definitive
    • Mice: B6C3F1
  • Salmonella  (G12103)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R12103B)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 5, 20 or 60 mg/kg/day; 25/animals per group.
  • GD 7 to GD 28 Conventional Teratology (Gavage)  (R12103D)  Completed 
    • Investigative Study
    • Rabbit: New Zealand White
    • Dose: 0, 25, 75, 150, or 300 mg/kg/group; 8 rabbits/group.
  • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R12103)  Completed 
    • Teratology Dose Range Finder (DRF)
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 20, 40, 80, 160, or 320 mg/kg.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.