National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-12103

Testing Status of Vinpocetine - 12103

 

CASRN: 42971-09-5

Formula: C22-H26-N2-O2

Synonyms/Common Names

  • Cavinton

Known Uses

Drug/therepeutic agent. Cerebrovascular agent; CNS agent; neuroprotective agent; phosphodiesterase inhibitor; vasodialator agent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Modified One-Generation

  • GD 6 - 20 Dose Range Finding (Gavage)  (MOG12103)  Assigned 
    • Perinatal
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 20, 40, 80, 160, or 320 mg/kg/day.

Special Studies

  • Toxicokinetic Study (Gavage)  (K12103)  Report in Preparation 
    • Female Rats: Harlan Sprague-Dawley

Genetic Toxicology

  • Comet Assay  (G12103D)  On Test 
    • Micronucleus (Gavage)  (G12103B)  On Test 
      • Ranger-finder female
      • Mice: B6C3F1
    • 3 days Micronucleus (Gavage)  (G12103C)  On Test 
      • Definitive
      • Mice: B6C3F1
    • Salmonella  (G12103)  Completed 
      •  Negative 

    Organ Systems Toxicity

    • GD 6 to GD 20 Conventional Teratology (Gavage)  (R12103B)  Completed 
      • Female Rats: Harlan Sprague-Dawley
      • Dose: 0, 5, 20 or 60 mg/kg/day; 25/animals per group.
    • GD 7 to GD 28 Conventional Teratology (Gavage)  (R12103D)  Completed 
      • Investigative Study
      • Rabbit: New Zealand White
      • Dose: 0, 25, 75, 150, or 300 mg/kg/group; 8 rabbits/group.
    • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R12103)  Completed 
      • Teratology Dose Range Finder (DRF)
      • Female Rats: Harlan Sprague-Dawley
      • Dose: 0, 20, 40, 80, 160, or 320 mg/kg.
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.