National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-122349

Testing Status of Simazine - 122349

 

CASRN: 122-34-9

Formula: C7-H12-Cl-N5

Synonyms/Common Names

  • Princep
  • 1,3,5-Triazine-2,4-diamine, 6-chloro-N,N'-diethyl- (9CI)

Known Uses

Herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 days (Gavage)  (C122349)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 63 mg/kg/day.

Genetic Toxicology

  • (G122349)  On Test 

    Toxicogenomics

    • 4 days Microarray Analysis (Gavage)  (T122349)  Completed 
      • Liver Targeted Testing study of Toxcast Chemicals
      • Rats: Harlan Sprague-Dawley
      • Dose: 63 mg/kg; 6 rats.
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.