Testing Status of 1-Chloro-2-propanol, technical 127004
CASRN: 127-00-4
Related: 1-CHLORO-2-PROPANOL
Formula: C3-H7-Cl-O
Synonyms/Common Names
- 1-Chloro-2-propanol
Known Uses
Chemical intermediate for propylene oxide & other organic compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.
Chemical Properties
Toxicity Effects (HSDB)
Short-Term Toxicity
- 14-Day (Dosed-Water)
(C61983A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 14-Day (Inhalation)
(C61983B)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13 weeks (Dosed-Water)
(C61983A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M:0, 100, 330, 1000, 3300, 10000 PPM.
Long-Term Carcinogenicity
- 2 years (Dosed-Water)
(C61983C)
Report Complete
- TR-477 (NIH Number: 98-3967)
(Peer Review Approval 12/10/1997A )
Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 150, 325, OR 650 PPM M: 0, 250, 500, OR 1000 PPM (50/SEX/GROUP).
- TR-477 (NIH Number: 98-3967)
(Peer Review Approval 12/10/1997A )
Genetic Toxicology
- Micronucleus
(A34020)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(A61208)
Completed
- Mice: MICE
- Male Negative
- Female Negative