Testing Status of 1-Chloro-2-propanol, technical 127004

CASRN: 127-00-4

Formula: C3-H7-Cl-O

Synonyms/Common Names

1-Chloro-2-propanol

Known Uses

Chemical intermediate for propylene oxide & other organic compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

14-Day (Dosed-Water) (C61983A) Completed
- Rats: F344/N; Mice: B6C3F1
14-Day (Inhalation) (C61983B) Completed
- Rats: F344/N; Mice: B6C3F1
13 weeks (Dosed-Water) (C61983A) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M:0, 100, 330, 1000, 3300, 10000 PPM.

Long-Term Carcinogenicity

2 years (Dosed-Water) (C61983C) Completed
- TR-477 (NIH Number: 98-3967) (Peer Review Approval 12/10/1997A )
  Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
- Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
  - Male Rats No Evidence
  - Female Rats No Evidence
  - Male Mice No Evidence
  - Female Mice No Evidence
- Dose: R: 0, 150, 325, OR 650 PPM M: 0, 250, 500, OR 1000 PPM (50/SEX/GROUP).

Genetic Toxicology

Micronucleus (A34020) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
Micronucleus (A61208) Completed
- Mice: MICE
- Male Negative
- Female Negative