National Toxicology Program

Testing Status of 1-Chloro-2-propanol, technical - 127004

CASRN: 127-00-4

Related: 1-CHLORO-2-PROPANOL

Formula: C3-H7-Cl-O

Synonyms/Common Names

• 1-Chloro-2-propanol

Known Uses

Chemical intermediate for propylene oxide & other organic compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

• 14-Day (Dosed-Water)  (C61983A)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 14-Day (Inhalation)  (C61983B)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13 weeks (Dosed-Water)  (C61983A)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M:0, 100, 330, 1000, 3300, 10000 PPM.

Long-Term Carcinogenicity

• 2 years (Dosed-Water)  (C61983C)  Report Complete 
  • TR-477 (NIH Number: 98-3967)  (Peer Review Approval 12/10/1997A )
    Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 150, 325, OR 650 PPM M: 0, 250, 500, OR 1000 PPM (50/SEX/GROUP).

Genetic Toxicology

• Micronucleus  (A34020)  Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A61208)  Completed 
  • Mice: MICE
  • Male Negative 
  • Female Negative