National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-129793

Testing Status of 2,4,7-Trinitro-fluoren-9-one - 129793

 

CASRN: 129-79-3

Formula: C13-H5-N3-O7

Synonyms/Common Names

  • 9H-Fluoren-9-one, 2,4,7-trinitro-

Known Uses

Used in photocopiers, forms charge-transfer complexes with aromatic hydrocarbons and amines.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C61961A)  Completed 
    • Mice: B6C3F1
  • 3 weeks (Topical Application)  (C61961A)  Completed 
    • Rats: F344/N
  • 2 weeks (Dosed-Feed)  (C61961B)  Completed 
    • Mice: B6C3F1
  • 3 weeks (Dosed-Feed)  (C61961B)  Completed 
    • Rats: F344/N
  • 13 weeks (Dosed-Feed)  (C61961B)  Report Complete 
    • TOX-13 (NIH Number: 92-3132)
      Toxicity Studies of Trinitrofluorenone (CASRN 129-79-3) Administered by Topical Application and Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1000, 2000, 4000, 8000, 16000; M: 0, 3212, 6250, 12500, 25000, 55000 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection; Intravenous; Topical Application)  (S0231)  Completed 
    • Male Rats: F344/N
    • Dose: OR:10; IV & IP:1 MG/KG DER:47, 400 MICG/CM2.

Genetic Toxicology

  • Micronucleus  (A44104)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (300390)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM91032)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0,1,3,&5% WITH FCA; 0,3,5% NO FCA; DNFB AT 0 AND 0.5% AS POS. CONTROL.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.