National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-13067

Testing Status of Tricombination FTC:TDF:EFV (1:1.5:3) - 13067

 

CASRN: TRICOMBOHIV

Formula: C19H30N5O10P.C14H9ClF3NO2.C8H10FN3O3S.C4H4O4

Synonyms/Common Names

  • Tri-Combo Therapy (TDF/EFV/FTC)
  • Tri-combo therapy (TDF/EFV/FTC) (AIDS)

Secondary:

  • 154598-52-4 - Efavirenz (EFV)
  • 143491-57-0 - Emtricitabine (FTC)
  • 202138-50-9 - Tenofovir Disoproxil Fumarate (TDF)

Known Uses

Tri-combo therapy of Tenofovir Disopropxil fumarate (TDF), Efavirenz (EFV) and Emtricitabine (FTC) used in HIV treatment. Efavirenz mixture with emtricitabine, tenofovir and disoproxil fumarate.

Special Studies

  • GD 5 - GD 15 Preliminary Toxicokinetic Study (Gavage) Selected (K13067)  
    • Mice

Organ Systems Toxicity

  • GD 5-15 Maternal Transfer (Gavage)  (R13067D)  Completed 
    • Mice: CD-1
    • Dose: Emtricitabine 50 mg/kg/day, Tenofovir 75 mg/kg/day, and Efavirenz 150 mg/kg/day.
  • Selected (R13067C)  
    • Teratology Pilot Studies Selected (R13067B)  
      • Teratology
      • Mice: CD-1
    • GD 5 - GD 18 Teratology Pilot Studies (Gavage)  (R13067)  Completed 
      • Dose Range-Finding
      • Mice: CD-1
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.