National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-13113

Testing Status of Lipopolysaccharides from Escherichia coli - 13113

 

CASRN: ECOLI_LPS

Formula: N/A

Synonyms/Common Names

  • LPS
  • LPS

Known Uses

Lipopolysaccharides (LPS), also known as lipoglycans, are large molecules consisting of a lipid and apolysaccharide joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria, act as endotoxins and elicit strong immune responses in animals.

Short-Term Toxicity

  • 4 days (Intraperitoneal Injection)  (C13113)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 2 mg/kg/day.

Toxicogenomics

  • 4 days Microarray Analysis (Intraperitoneal Injection)  (T13113)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: not provided; 6 rats.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.