National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-1314870

Testing Status of Lead sulfide - 1314870

 

CASRN: 1314-87-0

Formula: Pb-S

Synonyms/Common Names

  • Plumbous sulfide

Known Uses

Glazing earthenware, ore in lead production, photoresistor component in infrared radiation detectors, catalyst in petroleum sweetening, lead zinc oxides, in blue basic lead sulfate, density agent in drilling fluids. In manufacture of semiconductors.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 & 26 weeks (Dosed-Feed)  (C88040B)  Completed 
    • Rats: F344/N
    • Dose: RATS: MALE AND FEMALE 0, 10, 30, 100 PPM, 10/GROUP 30, 60, 90, 180 DAY SAC.
  • 4 weeks (Dosed-Feed)  (C88040)  Completed 
    • Rats: F344/N
    • Dose: MR: 0, 10, 30, OR 100 PPM; 10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0265)  Completed 
    • Citation: Distribution of Lead in Rats after Repeated Exposure to Lead Compounds in Feed.
    • Male Rats: F344/N
    • Dose: 10, 30, 100 PPM.
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0477)  Completed 
    • Citation: Dieter MP, Matthews HB, Jeffcoat RA, Moseman RF. Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska. J Toxicol Environ Health. 1993 May;39(1):79-93.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0,10,30 OR 100 PPM.

Genetic Toxicology

  • Chromosome Aberrations  (A89452)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A82989)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (A87030)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.