National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-1319773

Testing Status of Cresols - 1319773

 

CASRN: 1319-77-3

Formula: C7-H8-O

Synonyms/Common Names

  • Cresols (Mixed Isomers Of ortho, meta, para)
  • Cryslol
  • Hydroxytoluene
  • Methylphenol (9CI)
  • Tricresol

Known Uses

Household disinfectant, paintbrush cleaner, in lubricating oils, fumigant, photographic developers, explosives, organic intermediate in production of coumarin, salicylaldehyde, synthetic resins, degreasing compounds, obtained from coal tar (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C62260)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62260)  Report Complete 
    • TOX-09 (NIH Number: 92-3128)
      Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, .03, .1, .3, 1.0, 3.0% IN DIET.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C62260B)  Report Complete 
    • TR-550 (NIH Number: 08-5891)  (Peer Review Approval 05/17/2007A )
      Toxicology and Carcinogenesis Studies of Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 1500, 5000, or 15, 000 PPM and M: 0, 1000, 3000, or 10, 000 PPM; 50/species/dose.

Genetic Toxicology

  • Micronucleus  (A73499)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (990849)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (A67379)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90003)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Meta-/Para-Cresol (MCPRE) in CD-1 Swiss Mice
    • Mice: Swiss
    • Dose: 0, 0.25, 0.5, 1.0, 2.0, 3.0%; 0, 0.25, 1.0, 1.5%; 0, 1.5%; 0, 0.25, 1.0, 1.5%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.