National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-134623

Testing Status of N,N-Diethyl-m-toluamide - 134623

 

CASRN: 134-62-3

Formula: C12-H17-N-O

Synonyms/Common Names

  • Autan
  • Benzamide, N,N-diethyl-3-methyl-
  • Chemform
  • DEET
  • DETA
  • Dieltamid
  • MGK
  • Naugatuck DET

Known Uses

Insect repellent for human use

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Genetic Toxicology

  • Salmonella  (623410)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • once daily, 5 days per weeks for 9 weeks Dominant Lethal (Intraperitoneal Injection)  (T0102A)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 0.3 AND 0.73 ML UNDILUTED MDET/KG/D.
  • once daily, 5 day/week for 9 weeks: pups sired by MDET-treated males Continuous Breeding (Legacy) (Intraperitoneal Injection)  (T0102B)  Completed 
    • Male Rats: Sprague Dawley
    • Dose: 0.3 AND 0.73 ML UNDILUTED MDET/KG/DAY.
  • 6 to 15 GD (vaginal sperm = 0 GD) Short-Term in vivo Repro. Tox. (Intraperitoneal Injection)  (T0102C)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0.3 ML UNDILUTED MDET/KG/DAY (PROJECTED LD10).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.