Testing Status of 4-Methylcyclohexanemethanol 14001

 

CASRN: 34885-03-5

Formula: C8-H16-O

Synonyms/Common Names

  • Cyclohexanemethanol, 4-methyl-
  • MCHM

Known Uses

Industrial Function: flotation agent. Reagent.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C14001)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 8 rats in 0 mg/kg group, 6 rats in each treated group.

Special Studies

  • C. elegans  (W14001)  Completed 
    • C. elegans: N2
    • Dose: Feeding: 200, 100, 75uMRepro: 200, 100, 75, 50uM.

Genetic Toxicology

  • Micronucleus  (G14001)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
  • Salmonella  (G14001B)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 7 days Immunotoxicity (Topical Application)  (I14001)  Completed 
    • Female Mice: BALB/c
    • Dose: 2, 20, or 100%.
  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R14001B)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 50, 100, 200, or 400 mg/kg.
  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R14001)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 150, 300, 600, or 900 mg/kg.

Other

  • Zebrafish Developmental Selected
  • High Throughput Screening Selected
  • Structure Activity Relationship (SAR) Analysis Selected

Toxicogenomics

  • Microarray Analysis (Gavage)  (T14001)  Completed 
    • Short Term Toxicogenomic Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: 0.1, 1, 10, 100, 300, or 500 mg/kg; 6 rats/dose group.