National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-14013

Testing Status of Crude MCHM - 14013

 

CASRN: CRUDEMCHM

Secondary:

  • 94-60-0 - Dimethyl 1,4-cyclohexanedicarboxylate
  • 105-08-8 - 1,4-Cyclohexanedimethanol
  • 67-56-1 - Methanol
  • 98955-27-2 - 4-Methoxymethylcyclohexylmethanol
  • 51181-40-9 - Methyl 4-methylcyclohexanecarboxylate
  • 34885-03-5 - 4-Methylcyclohexanemethanol

Known Uses

Industrial Function: flotation agent.

Short-Term Toxicity

  • 5 days (Gavage)  (C14013)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 0.1, 1, 10, 100, 300, or 500 mg/kg; 8 rats in 0 mg/kg group, 6 rats in each treated group.

Special Studies

  • C. elegans  (W14013)  Completed 
    • C. elegans: N2

Genetic Toxicology

  • Micronucleus  (G14013)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
  • Salmonella  (G14013B)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 7 days Immunotoxicity (Topical Application)  (I14013B)  Completed 
    • Female Mice: BALB/c
    • Dose: 1, 5, 25, 50, or 75.
  • 7 days Immunotoxicity (Topical Application)  (I14013)  Completed 
    • Female Mice: BALB/c
    • Dose: 1, 2, 5, 20, 40, or 100%.

Toxicogenomics

  • Microarray Analysis (Gavage)  (T14013)  Completed 
    • Short Term Toxicogenomic Studies
    • Rats: Harlan Sprague-Dawley

Other

  • Zebrafish Developmental Selected
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.