National Toxicology Program

National Toxicology Program

Testing Status of 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione - 14046


CASRN: 105624-86-0

Formula: C20H21NO3

Synonyms/Common Names

  • 5-Hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
  • 5HPP-33

Known Uses

A thalidomide derivative with cell-proliferation inhibitory properties 5HPP-33 exhibits antiproliferative, antimitotic, and microtubule-stabilizing activities. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (W14046)  Completed 
    • C. elegans
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.