National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-15037

Testing Status of Aloin - 15037

 

CASRN: 1415-73-2

Related: Aloin A

Formula: C21H22O9

Synonyms/Common Names

  • 1,8-Dihydroxy-3-hydroxymethyl-10-(6-hydroxymethyl-3,4,5-trihydroxy-2-pyranyl)anthrone
  • 10-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone

Known Uses

Aloin, a natural mixed diastereomer (A/B) anthracycline from aloe plant, may be studied as a chemopreventive factor and antineoplastic agent. Aloin inhibits angiogenesis, enhances melanogenesis and regulates transglutaminase activity. Aloin may be used to assess its activity as a selective phosphodiesterase inhibitor. Aloin A is used as a stabilizer in the preparation of gold and silver nanoparticles.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C15037)  On Test 
    • Rats: F344 (NCTR)
    • Dose: MR: 0, 6.95. 13.9, 27.8, 55.7, 111, 223, or 446 ppm; 10 per/group.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.