Testing Status of Tripelennamine hydrochloride 154698

 

CASRN: 154-69-8

Formula: C16-H21-N3.Cl-H

Synonyms/Common Names

  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride (9CI)

Known Uses

Antihistaminic agent, sunburn treatment

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C60662)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C60662)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 150, 300, 600, 1200, OR 2400 PPM M: 0, 300, 600, 1200, 2400, OR 48OO PPM.

Long-Term Carcinogenicity

  • 11 months (Dosed-Feed)  (C60662)  Terminated 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 200, OR 400 PPM M: 0, 500, 1000, OR 2000 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (751148)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (861294)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative