Testing Status of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine 16011

 

CASRN: 95737-68-1

Formula: C20-H19-N-O3

Synonyms/Common Names

  • MPEP
  • MPPE
  • Pyridine, 2-[1-methyl-2-(4-phenoxyphenoxy)ethoxy]-
  • 2-[1-methyl-2-(4-phenoxyphenoxy)ethoxy]pyridine
  • Pyriproxyfen

Known Uses

Agricultural Chemical, Insecticide Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K16011B)  On Test 
    • Female Rabbit
    • Dose: 0, 62.5, or 125 mg/kg/day.
  • GD 6-18 Toxicokinetic Study (Gavage)  (K16011)  On Test 
    • Pilot TK (Pilot Fetal Transfer Study on MPEP)
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 62.5, 250 mg/kg per day.

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (I16011B)  On Test 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 63, 125, 250, or 500 mg/kg/day.
  • 28 days Immunotoxicity (Gavage)  (I16011)  On Test 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 63, 125, 250, or 500 mg/kg/day.
  • GD 7-28 Conventional Teratology (Gavage)  (R16011B)  Report in Review 
    • Rabbit Teratology
    • Female Rabbit: New Zealand White
    • Dose: Rabbit: 0, 62.5, 125, 250, or 500 mg/kg/day.
  • 3 weeks Conventional Teratology (Gavage)  (R16011D)  Assigned 
    • Prenatal Toxicity Study of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CAS# 95737-68-1) in New Zealand White Rabbits Exposed Via Gavage
    • Female Rabbit: New Zealand White
  • GD 6-21 Conventional Teratology (Gavage)  (R16011)  Report in Review 
    • Rat Teratology
    • Female Rats: Hsd:Sprague Dawley SD
    • Dose: Rat: 0, 62.5, 125, 250, or 500 mg/kg/day.
  • Teratology Pilot Studies (Gavage)  (R16011C)  Assigned 
    • Dose Range Finding Prenatal Toxicity Study of 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (CAS# 95737-68-1) in New Zealand White Rabbits Exposed Via Gavage
    • Female Rabbit: New Zealand White
    • Dose: 0, 300, 400 and 500 mg/kg/day.