Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of t-Butylhydroquinone 1948330

 

CASRN: 1948-33-0

Formula: C10-H14-O2

Synonyms/Common Names

  • 1,4-Benzenediol, 2-(1,1-dimethylethyl)-
  • MTBHQ

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C62157)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, OR 4.0% IN FEED.

Long-Term Carcinogenicity

  • lifetime (Dosed-Feed)  (C62157)  Completed 
    • TR-459 (NIH Number: 97-3375)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE.

Genetic Toxicology

  • Chromosome Aberrations  (A73022)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (089956)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A34876)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (663851)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (A71156)  Completed 
    •  Equivocal 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM87036)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 25, 75, 150 MG/KG.