National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-1948330

Testing Status of t-Butylhydroquinone - 1948330

 

CASRN: 1948-33-0

Formula: C10-H14-O2

Synonyms/Common Names

  • 1,4-Benzenediol, 2-(1,1-dimethylethyl)-
  • MTBHQ

Known Uses

Antioxidant in cosmetic products, skin care preparations, vegetable fats and oils, meat products to prevent rancidity, and as a polymerization inhibitor for various polyunsaturated polyesters. Intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C62157)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, OR 4.0% IN FEED.

Long-Term Carcinogenicity

  • lifetime (Dosed-Feed)  (C62157)  Report Complete 
    • TR-459 (NIH Number: 97-3375)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE.

Genetic Toxicology

  • Chromosome Aberrations  (A73022)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (089956)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A34876)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (663851)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (A71156)  Completed 
    •  Equivocal 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM87036)  Completed 
    • Female Mice: B6C3F1
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.