National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-2426086

Testing Status of n-Butyl Glycidyl Ether - 2426086

 

CASRN: 2426-08-6

Formula: C7-H14-O2

Synonyms/Common Names

  • Oxirane, (butoxymethyl)-

Known Uses

Modifier for synthetic fibers and resins; stabilizer for chlorinated organic compounds; viscosity-reducing agent; acid acceptor for solvents; chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C20525)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500 OR 1000 PPM; 5/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0938)  Completed 
    • Citation: Chen LJ, Lebetkin EH, Nwakpuda EI, Burka LT. Metabolism and disposition of n-butyl glycidyl ether in F344 rats and B6C3F1 mice. Drug Metab Dispos. 2007 Dec;35(12):2218-24. Epub 2007 Sep 17.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 2,20, 200 MG/KG.

Genetic Toxicology

  • Micronucleus  (A70390)  Completed 
    • Mice: B6C3F1
  • Micronucleus  (A92337)  Completed 
    • Rats: F344/NTac
  • Salmonella  (095791)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
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