National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-2608482

Testing Status of 5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) - 2608482

 

CASRN: 2608-48-2

Formula: C11-H9-N-O3

Synonyms/Common Names

  • NPPD
  • Spy Dust

Known Uses

Spy dust

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C87002B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Topical Application)  (C87002)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0076)  Completed 
    • Citation: Burka LT, Sanders JM, Kool CP, Kim YC, Matthews HB. Absorption and metabolism of 5-(4-nitrophenyl)-2,4-pentadienal (Spydust). Toxicol Appl Pharmacol. 1987 Jan;87(1):121-6.Pubmed Abstract
    • Male Rats: F344/N; Male Rats

Genetic Toxicology

  • Chromosome Aberrations  (A84710)  Completed 
    • Citation: Zeiger, E., M.D. Shelby, J. Ivett, and A.F. McFee Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (Spy Dust) and its metabolites in vitro and in vivo Environmental Mutagenesis Vol. 9 (1987) 269-280
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (073716)  Completed 
    • Citation: Zeiger, E., Shelby, M., Ivett J., and McFee, A. Mutagenicity testing of 5-(4-nitrophenyl)-2, 4-pentadien-1-al ("Spy Dust") and its metabolites in vitro and in vivo. Environ. Mutagen. Vol. 9 (1987) 269-280
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A63788)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Female Positive (Nonstandard Protocol) 
  • Sister Chromatid Exchanges  (A84710)  Completed 
    • Citation: Zeiger, E., M.D. Shelby, J. Ivett, and A.F. McFee Mutagenicity testing of 5-(4-nitrophenyl)-2,4-pentadien-1-al (Spy Dust) and its metabolites in vitro and in vivo Environmental Mutagenesis Vol. 9 (1987) 269-280
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.