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Testing Status of Treosulfan 299752

 

CASRN: 299-75-2

Formula: C6-H14-O8-S2

Synonyms/Common Names

  • 1,4-Bis-O-Methanesulfonyl-L-threitol
  • 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]- (9CI)
  • Dihydroxybusulfan

Known Uses

Alkylating agent used in treatment of all stages of ovarian cancer. Treosulfan is a bifunctional alkylating prodrug with activity against various solid tumors.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (730810)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice: B6C3F1
    • Male Positive