National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-302794

Testing Status of trans-Retinoic acid - 302794

 

CASRN: 302-79-4

Formula: C20-H28-O2

Synonyms/Common Names

  • Retinoic acid (9CI)

Known Uses

Keratolytic agent, medication for treatment of acne, vitamin A derivative (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Mechanisms (Gavage)  (S0485)  Completed 
    • Citation: Abbott BD, Hill LG, Birnbaum LS. Processes involved in retinoic acid production of small embryonic palatal shelves and limb defects. Teratology. 1990 Mar;41(3):299-310.Pubmed Abstract
    • Female Mice: C57BL/6
    • Dose: 100 MG/KG.
  • Mechanisms (Gavage)  (S0687)  Completed 
    • Citation: Abbott BD, Birnbaum LS. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. Toxicol Appl Pharmacol. 1989 Jun 15;99(2):287-301.Pubmed Abstract
    • Male and Female Mice: C57BL/6
  • C. elegans  (S0924)  Completed 
    • C. elegans
    • Dose: Feed: (0,10,16,25,40,63,100,16-,250,400,630,1000)uM; repro: (0,10,16,25,40,63,100,16-,250,400,630,1000)uM growth: (0,2.5,4,6.3,10,16,25,40,63,100,160,250,) uM.

Organ Systems Toxicity

  • single Preimplantation Zygote Effects (Intraperitoneal Injection)  (PZE98001)  Completed 
    • Citation: Rutledge, JC, Shourbaji, AG, Hughes, LA, Polifka, JE, Cruz, UP, Bishop, JB, and Generoso, WM. Limb and lower-body duplications induced by retinoic acid in mice. Proc. Natl. Acad. Sci. USA 91:5436-5440 (1994).
    • Female Mice: (C3H X C57BL10)F1
    • Mice Female Positive 
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0108A)  Completed 
    • Female Mice: Swiss
  • 7, 8, 9 or 10 GD Conventional Teratology (Gavage)  (TER86130)  Completed 
    • Female Hamsters: LVG (SYR)
    • Hamsters Maternal Inadequate 
    • Hamsters Fetal Inadequate 
    • Dose: 60 MG/KG ON GD 7; 80 MG/KG ON GD 8-10.
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