National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-3056175

Testing Status of 2',3'-Didehydro-3'-deoxythymidine - 3056175

 

CASRN: 3056-17-5

Related: DDI

Formula: C10-H12-N2-O4

Synonyms/Common Names

  • D4T
  • D 4T
  • Stavudine

Known Uses

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (665471)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (537402)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (420717)  Completed 
    •  Weakly Positive 
  • Salmonella  (A41441)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90016)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicological Evaluation Of AIDS Therapeutics, Task II-A Report: Dideoxydidehydrothymidine (d4T)
    • Female Mice: C57BL/6 And DBA/2
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