Testing Status of Emodin 518821

 

CASRN: 518-82-1

Formula: C15-H10-O5

Synonyms/Common Names

  • 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione
  • 1,3,8-Trihydroxy-6-methylanthraquinone

Known Uses

Major component of natural laxative drugs of plant origin. Medicine. Natural plant dye.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C62408)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.06, 0.2, 0.55, 1.2, OR 5% IN FEED.
  • 13 weeks (Dosed-Feed)  (C62408)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.03, 0.06, 0.125, 0.25, OR 0.5% IN FEED.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C62408)  Report Complete 
    • TR-493 (NIH Number: 01-3952)  (Peer Review Approval 05/21/1999A )
      Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0322)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: RATS & MICE IV 2 MG/KG BW; GAV 20 & 150 MG/KG BW.
  • Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (S0575)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 90D: 0.03, 0.06, 0.125, 0.25 OR 0.5% IN FEED, BLOOD, PAR; 104W: RAT 280, 830 OR 2500 PPM, MICE 160, 312, 625 OR 1250 PPM IN FEED, BLOOD, 90D: FEED, BLOOD, 104W: FEED, BLOOD, .
  • C. elegans  (W518821)  Completed 
    • C. elegans
    • Dose: 100, 75, 50 uM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A00749)  Completed 
    • Sister Chromatid Exchange Not Tested 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A43429)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A58400)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Micronucleus  (A88319)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (278686)  Completed 
    •  Weakly Positive 
  • Salmonella  (399853)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 6 to 20 GD Conventional Teratology (Dosed-Feed)  (TER98003)  Completed 
    • Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SPRAGUE DAWLEY (CD®) RATS ON GESTATIONAL DAYS 6 TO 20
    • Citation: Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Sprague Dawley (CD®) Rats on Gestational Days 6 to 20
    • Female Rats: Sprague Dawley
    • Dose: 0, 425, 850, OR 1700 PPM.
  • 6 to 17 GD Conventional Teratology (Dosed-Feed)  (TER99003)  Completed 
    • Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CASRN 518-82-1) ADMINISTERED IN THE FEED TO?SWISS (CD-1®) MICE ON GESTATIONAL DAYS 6 TO 17
    • Citation: Developmental Toxicity Evaluation of Emodin (CASRN 518-82-1) Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6 to 17
    • Female Mice: Swiss CD-1
    • Dose: 0, 600, 2500, OR 6000 PPM.
  • 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)  (TRP98003)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 1700, 3400, 6750, 10, 000 OR 13, 500 PPM.
  • 6 to 17 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99006)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 750, 1500, 3000, 4500, OR 6000 PPM.