National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-538238

Testing Status of Tricaprylin - 538238

 

CASRN: 538-23-8

Formula: C27-H50-O6

Synonyms/Common Names

  • Octanoic acid, 1,2,3-propanetriyl ester (9CI)

Known Uses

Fractionated coconut oil const, in preparation of oral suspensions of drugs unstable in aqueous media (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C62215)  Report Complete 
    • TR-426 (NIH Number: 94-3157)  (Peer Review Approval 12/01/1992A )
      Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CASRNs 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage
    • Rats: F344/N
    • Dose: RATS ONLY: 0, 2.5, 5, 10 ML/KG/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (634522)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0110)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 4750 (UNDILUTED) MG/KG BODY WEIGHT.
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