National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-555306

Testing Status of Methyl dopa - 555306

 

CASRN: 555-30-6

Related: METHYL DOPA SESQUIHYDRATE

Formula: C10-H13-N-O4

Synonyms/Common Names

  • 3-Hydroxy-alpha-methyl-L-tyrosine

Known Uses

Pharmaceutical, antihypertensive agent

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (003933)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (572845)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (921912)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Micronucleus  (A34520)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (515921)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 

Organ Systems Toxicity

  • 6 to 20 GD Conventional Teratology (Gavage)  (TER85090)  Completed 
    • Citation: Teratologic Evaluation of Alpha-Methyldopa Administered to CD Rats on Gestational Days 6-20
    • Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 50, 100, 250, 500 MG/KG/DAY.
  • 6 to 17 GD Conventional Teratology (Gavage)  (TER86091)  Completed 
    • Citation: Teratologic Evaluation of Alpha-Methyldopa Administered tp CD-1 Mice on Gestational Days 6 through 17
    • Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 100, 250, 500, 750 MG/KG/DAY.
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