National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-57749

Testing Status of Chlordane (analytical grade) - 57749

 

CASRN: 57-74-9

Related: 12789-03-6

Formula: C10-H6-Cl8

Synonyms/Common Names

  • 4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-

Known Uses

Insecticide

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00099)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00099)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: MR: 0, 50, 1600, FR: 0, 100, 1600, M: 0, 20, 640 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00099)  Report Complete 
    • TR-008 (NIH Number: 77-808)  (Peer Review Approval NA)
      Bioassay of Chlordane for Possible Carcinogenicity (CASRN 57-74-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0, 120.8, 241.5 (AVG), MR: 0, 203.5, 407 (AVG), FM: 0, 30.1, 63.8 (AVG), MM: 0, 29.9, 56.2 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (675840)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (779361)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
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