National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-57976

Testing Status of Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) - 57976

 

CASRN: INIT/PROM

Formula: C20-H16 / C36-H56-O8 / C14-H10-O4 / C2-H5-N5-O3

Synonyms/Common Names

  • Benzoyl peroxide
  • Benzoyl peroxide
  • 7,12-Dimethylbenz(A)anthracene
  • 7,12-Dimethylbenz(A)anthracene (DMBA)
  • DMBA/TPA/BPO/MNNG
  • N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)
  • N-Methyl-N'-nitro-N-nitrosoguanidine
  • Tetradecanoylphorbol acetate (TPA)
  • Tetradecanoylphorbol acetate

Secondary:

  • 94-36-0 - Benzoyl peroxide
  • 57-97-6 - 7,12-Dimethylbenzanthracene
  • 70-25-7 - 1-Methyl-3-nitro-1-nitroso-guanidine
  • 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
  • 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

Known Uses

Tumor initiator and promoter

Long-Term Carcinogenicity

  • 1 year (Topical Application)  (C61994A)  Report Complete 
    • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
      Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
    • Mice: B6C3F1
    • Dose: DMBA/ACETONE(50, 25, 2.5UG), DMBA 2.5, TPA 5UG, BPO 20MG, DMBA/TPA(2.5, 25, 50UG/5UG), DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG), MNNG 100UG, TPA 5UG, BPO 20MG, MNNG/BPO(100, 500, 1000UG/20MG), MNNG/TPA(100, 1000UG/5UG).
  • 1 year (Topical Application)  (C61994B)  Report Complete 
    • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
      Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
    • Mice: Swiss CD-1
    • Dose: DMBA/ACETONE(25, 2.5, .25UG), DMBA 2.5, TPA 5 UG, BPO 20MG, DMBA/TPA(.25, 2.5, 25/5UG), DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG), MNNG 100UG, TPA 5UG, BPO 20MG, MNNG/BPO(100, 500, 1000UG/20MG), MNNG/TPA(1000, 1000UG/5UG).
  • 1 year (Topical Application)  (C61994C)  Report Complete 
    • TR-441 (NIH Number: 96-3357)  (Peer Review Approval 06/21/1994A )
      Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
    • Mice: B6C3F1; Mice: Sencar; Mice: Swiss CD-1
    • Dose: DMBA/ACETONE(25, 2.5, .25UG):DMBA 2.5:TPA 1UG:BPO 20MG:DMBA/TPA(.25, 2.5, 25/1UG):DMBA/BPO(2.5, 25UG/20MG) AND MNNG/ACETONE(1000, 500, 100UG):MNNG 100UG:TPA 5UG:BPO 20MG:MNNG/BPO(100, 500, 1000 UG/20MG).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.