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Testing Status of 2,4-Toluene diisocyanate 584849


CASRN: 584-84-9

Formula: C9-H6-N2-O2

Synonyms/Common Names

  • 2,4-Diisocyanato-1-methylbenzene (9CI)
  • Isocyanic acid, 4-methyl-M-phenylene ester

Known Uses

Chemical intermediate. Cross-linking agent for Nylon-6.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0208)  Completed 

    Genetic Toxicology

    • In Vitro Cytogenetics (CA/SCE)  (644663)  Completed 
      • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
      • Sister Chromatid Exchange Equivocal 
      • Chromosome Aberrations Negative 
    • Mouse Lymphoma  (445615)  Completed 
      • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
      • Mice
      •  Positive 
    • Salmonella  (928398)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Positive