National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-59336

Testing Status of Pyrilamine maleate - 59336

 

CASRN: 59-33-6

Related: PYRILAMINE, CAS 91-84-9

Formula: C17-H23-N3-O.C4-H4-O4

Synonyms/Common Names

  • N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyridyl)ethylenediamine maleate

Known Uses

Antihistaminic

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0551)  Completed 
    • Citation: Cunningham ML, Pippin LL, Anderson NL, Wenk ML. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicol Appl Pharmacol. 1995 Apr;131(2):216-23.Pubmed Abstract
    • Male Rats
    • Dose: 1000 PPM.

Genetic Toxicology

  • Chromosome Aberrations  (A32244)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A47789)  Completed 
    • Mice: B6C3F1
    • Male Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.