National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-6055192

Testing Status of Cyclophosphamide monohydrate - 6055192

 

CASRN: 6055-19-2

Related: CYCLOPHOSPHAMIDE (CAS 50-18-0)

Formula: C7-H15-Cl2-N2-O2-P.H2-O

Known Uses

Used in treatment of Hodgkin disease and lymphosarcomas

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Comet Assay  (G10351B)  Completed 
    • Rats
  • In Vitro Cytogenetics (CA/SCE)  (661949)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (788617)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • (F29126)  Completed 
    • (F82553)  Completed 
      • Micronucleus  (813361)  Completed 
        • Rats/Mice: B6C3F1
        • Male Positive 
        • Female Positive 
      • Micronucleus  (A05549)  Completed 
        • Rats
        • Male Positive 
      • Micronucleus  (A17052)  Completed 
        • Mice: B6C3F1
        • Male Positive 
        • Female Positive 
      • Micronucleus  (A21264)  Completed 
        • Mice
        • Male Positive 
      • Micronucleus  (A25833)  Completed 
        • Rats: Fischer 344
        • Male Positive 
        • Female NA 
      • Micronucleus  (A57498)  Completed 
        • Mice: B6C3F1
        • Male Positive 
        • Female Positive 
      • Micronucleus  (A91782)  Completed 
        • Mice: B6C3F1
        • Male Positive 
        • Female Weakly Positive 
      • Micronucleus  (A95722)  Completed 
        • Mice: B6C3F1
        • Male Positive 
        • Female Positive 
      • Micronucleus  (F25833)  Completed 
        • Rats: Fischer 344
        • Male Positive 
        • Female NA 
      • Salmonella  (101998)  Completed 
        • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
        •  Positive 
      • Salmonella  (122836)  Completed 
        • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
        •  Positive 

      Organ Systems Toxicity

      • single treatment Sperm FISH (Fluorescence in situ hybridization) Aneuploidy (Gavage)  (FISH20204)  Completed 
        • Male Mice: B6C3F1
        • Dose: 120 MG/KG.
      NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.