National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-6112761

Testing Status of 6-Mercaptopurine monohydrate - 6112761

 

CASRN: 6112-76-1

Related: 6-MERCAPTOPURINE, CAS 50-44-2

Formula: C5-H4-N4-S.H2-O

Synonyms/Common Names

  • 6H-Purine-6-thione, 1,7-dihydro-, monohydrate (9CI)

Known Uses

Antineoplastic

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Drosophila  (393298)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (100998)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM025)  Completed 
    • Citation: Russell, L.B. and Hunsicker, P.R. Study of the base analog 6-mercaptopurine in the mouse specific-locus test. Mutation Res. 176:47-52 (1987).
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Morphological Specific Locus  (MSLM44)  Completed 
    • Citation: Russell, L.B. and Hunsicker, P.R. Study of the base analog 6-mercaptopurine in the mouse specific-locus test. Mutation Res. 176:47-52 (1987).
    • Male Mice: 101 X C3H
    • Mice Male Negative 
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