Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Methanol 67561

 

CASRN: 67-56-1

Formula: C-H4-O

Synonyms/Common Names

  • MeOH
  • Methyl alcohol

Known Uses

Solvent, antifreeze, denaturant for ethyl alcohol, intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Mechanisms (in-vitro)  (S0225)  Completed 
    • Citation: Cunningham ML, Burka LT, Matthews HB. The interaction of methanol, rat-liver S9 and the aromatic amine 2,4-diaminotoluene produces a new mutagenic compound. Mutat Res. 1990 Aug;244(4):273-7.Pubmed Abstract
    • Citation: Cunningham ML, Matthews HB, Burka LT. Activation of methanol by hepatic postmitochondrial supernatant: formation of a condensation product with 2,4-diaminotoluene. Chem Res Toxicol. 1990 Mar-Apr;3(2):157-61. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 10 MOL.
  • C. elegans  (S0922)  Completed 
    • C. elegans
    • Dose: Feed (0, .032, .05, .079, .13, .2, .32, .5, .79, 1.3, 2, 3.2) M 12/13/06 Repro (0.12, .25, .37, .49, .62, .74, .86, .98, 1.23, 1.35, 1.48) M Growth (0, .49, .62, .79, .99, 1.23, 1.56, 1.95, 2.47, 3.21, 3.95, 4.94) M 07/09/07.

Genetic Toxicology

  • Salmonella  (A76470)  Completed 
    •  Equivocal 
  • Salmonella  (A76659)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 1 to 19 days (sperm = 0) (7 to 15 days at 2000 PPM) Conventional Teratology (Inhalation)  (T0015)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 5000, 10000, 20000 PPM.