National Toxicology Program

National Toxicology Program

Testing Status of Methanol - 67561


CASRN: 67-56-1

Formula: C-H4-O

Synonyms/Common Names

  • MeOH
  • Methyl alcohol

Known Uses

Solvent, antifreeze, denaturant for ethyl alcohol, intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Mechanisms (in-vitro)  (S0225)  Completed 
    • Citation: Cunningham ML, Burka LT, Matthews HB. The interaction of methanol, rat-liver S9 and the aromatic amine 2,4-diaminotoluene produces a new mutagenic compound. Mutat Res. 1990 Aug;244(4):273-7.Pubmed Abstract
    • Citation: Cunningham ML, Matthews HB, Burka LT. Activation of methanol by hepatic postmitochondrial supernatant: formation of a condensation product with 2,4-diaminotoluene. Chem Res Toxicol. 1990 Mar-Apr;3(2):157-61. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 10 MOL.
  • C. elegans  (S0922)  Completed 
    • C. elegans
    • Dose: Feed (0,.032,.05,.079,.13,.2,.32,.5,.79,1.3,2,3.2) M 12/13/06 Repro (0.12,.25,.37,.49,.62,.74,.86,.98,1.23,1.35,1.48) M Growth (0,.49,.62,.79,.99,1.23,1.56,1.95,2.47,3.21,3.95,4.94) M 07/09/07.

Genetic Toxicology

  • Salmonella  (A76470)  Completed 
    •  Equivocal 
  • Salmonella  (A76659)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 1 to 19 days (sperm = 0) (7 to 15 days at 2000 PPM) Conventional Teratology (Inhalation)  (T0015)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 5000,10000,20000 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.