Testing Status of Methyl vinyl ketone 78944

 

CASRN: 78-94-4

Formula: C4-H6-O

Synonyms/Common Names

  • Acetyl ethylene
  • 3-Buten-2-one (8CI)(9CI)
  • MVK
  • Vinyl methyl ketone

Known Uses

Alkylating agent. Intermediate in pharmaceutical synthesis. Component of ionomer resins. , monomer in production of plastics and resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C92005)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.25, 0.5, 1, 2, 4, OR 8 PPM.
  • 13 weeks (Inhalation)  (C92005)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.5, 1, OR 2 PPM.

Genetic Toxicology

  • Micronucleus  (A80150)  Completed 
    • Rats: Fischer 344
    • Male Equivocal 
  • Micronucleus  (A92643)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (876647)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive