National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-823405

Testing Status of 2,6-Diaminotoluene - 823405

 

CASRN: 823-40-5

Formula: C7-H10-N2

Synonyms/Common Names

  • 1,3-Benzenediamine, 2-methyl-

Known Uses

Chemical intermediate for dyes, rubber chemicals. Curing agent for epoxy resins, monomer. Chain extender and crosslinker for polymers.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0733)  Completed 
    • Citation: Cunningham ML, Burka LT, Matthews HB. Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic noncarcinogen. Drug Metab Dispos. 1989 Nov-Dec;17(6):612-7.Pubmed Abstract
    • Male Rats: F344/N
  • Cell Proliferation (Intravenous)  (S0734)  Completed 
    • Citation: Cunningham ML, Foley J, Maronpot RR, Matthews HB. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair - 2,6- and 2,4-diaminotoluene. Toxicol Appl Pharmacol. 1991 Mar 1;107(3):562-7.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Gavage)  (S0732)  Completed 
    • Citation: Cunningham ML, Burka LT, Matthews HB. Identification and mutagenicity of the urinary metabolites of the mutagenic noncarcinogen 2,6-diaminotoluene. Jrnl of Liquid Chromatography. 1989;12(8):1407-16.
    • Male Rats: F344/N
  • Other (Gavage & Dosed-Water)  (S0735)  Completed 
    • Citation: Hayward JJ, Shane BS, Tindall KR, Cunningham ML. Differential in vivo mutagenicity of the carcinogen/non-carcinogen pair 2,4- and 2,6-diaminotoluene. Carcinogenesis. 1995 Oct;16(10):2429-33.Pubmed Abstract
    • Mice: B6C3F1
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